Jill first appears in Resident Evil: Apocalypse (2004), the second film in the live-action series. In this version of the series she is a STARS member and foil to the main character, Alice. Jill tries to escape Raccoon City along with a group of survivors and is one of the few to make it out. She was set to appear in the sequel, Resident Evil: Extinction, but Sienna Guillory had commitments to other work. Later, producers Paul W.S. Anderson and Jeremy Bolt decided to have a separate game character (Claire Redfield) appear alongside the previous film's lead Alice: "We thought, rather than bring Jill back, put her with another game heroine."
Jill returns in a costume based on her Resident Evil 5 suit at the end of the film Resident Evil: Afterlife (2010). She is under the control of Umbrella Corporation, leading an attack against Alice, Claire, and Chris and the remaining human survivors. Guillory confirmed that she will be returning to the role of Jill in the fifth film, Resident Evil: Retribution.
Jill appears in several novels based on the Resident Evil series, particularly in those by S. D. Perry. In the 1998 novel Resident Evil: The Umbrella Conspiracy, Jill is said to be the daughter of professional thief Dick Valentine and to having been his accomplice prior to her career in law enforcement (in apparent conflict with her supposed Delta Force background), explaining her unrivaled infiltration skills and "mastery of unlocking".
She also appears in Lee Chung Hing's manhua adaptation of Nemesis, titled Biohazard 3: Last Escape (1999), as well as in the Marvel's comic series Resident Evil (1996–1998) and the comic book Marvel Vs. Capcom: Fate of Two Worlds (2011).